MYC Gene & Protein
Hu S, Xu-Monette ZY, Tzankov A, Green T, Wu L, Balasubramanyam A, Liu WM, Visco C, Li Y, Miranda RN, Montes-Moreno S, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, Zhao X, van Krieken JH, Huang Q, Huh J, Ai W, Ponzoni M, Ferreri AJM, Zhou F, Slack GW, Gascoyne RD, Tu M, Variakojis D, Chen W, Go RS, Piris MA, Møller MB, Medeiros LJ, Young KH. MYC/BCL2 protein co-expression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from the International DLBCL Rituximab-CHOP Consortium Program. Blood. 2013 May 16;121(20):4021-31. Quiz 4250. doi: 10.1182/blood-2012- 10-460063.
Plenary Paper. CME article. CME Questions. Blood. 2013 May121:4250
Chen Z, Hu S. MYC/BCL2 double-hit lymphoma mimicking acute leukemia at initial presentation. Blood. 2016 Feb 25;127(8):1072. doi: 10.1182/blood-2015-11-683730. PMID: 27351033
Hu Z, Medeiros LJ, Chen Z, Chen W, Li S, Konoplev SN, Lu X, Lan V Pham, Young KH, Wang W, Hu S. Mantle cell lymphoma with MYC rearrangement: A report of 17 patients. Am J Surg Pathol. 2017 Feb;41(2):216-224. doi: 10.1097/PAS.0000000000000758. PMID: 27776009
Liu H, Xu-Monette Z, Tang G, Wang W, Kim Y, Yuan J, Chen W, Li Y, Li Y, Zhu F, Fang X, Luedke C, Medeiros LJ, Young KH, Hu S. EBV-positive high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study. Histopathology. 2022 Feb;80(3):575-588. doi: 10.1111/his.14585. PMID: 34637146.
Liu H, Shen Q, Chang CC, Hu S. Phenotypic switch in high-grade B-cell lymphoma with MYC and BCL6 rearrangements: a potential mechanism of therapeutic resistance in lymphoma? Front Oncol. 2021 Dec 23;11:795330. doi: 10.3389/fonc.2021.795330. eCollection 2021. PMID: 35004320
Wang X, Tang G, Hu Z, Fang H, Wang W, Tang Z, Toruner GA, Zhou T, DiNardo CD, Garcia-Manero G, Verstovsek S, Bueso-Ramos CE, Medeiros LJ, Hu S. Myeloid neoplasms with 8q24/MYC rearrangement are frequently associated with myelodysplasia, complex karyotype, TP53 alterations, and inferior survival. Br J Haematol. 2022 Aug;198(3):604-608. doi: 10.1111/bjh.18278. PMID: 35645146.
Li Y, Hu S, Wang SA, Li S, Huh YO, Tang Z, Medeiros LJ, Tang G. The clinical significance of 8q245/MYC rearrangement in chronic lymphocytic leukemia. Mod Pathol. 2016 May;29(5):444-451. doi: 10.1038/modpathol.2016.35. PMID: 26916070
Wang W, Hu S, Lu X, Young KH, Medeiros LJ. Triple-hit B-cell lymphomas with MYC, BCL2 and BCL6 translocations/rearrangements: clinicopathologic features of 11 cases. Am J Surg Pathol. 2015 Aug;39(8):1132-9. doi: 10.1097/PAS.0000000000000434. PMID: 25828391
Wang X, Medeiros LJ, Lin P, Yin CC, Hu S, Thompson MA, Li S. MYC cytogenetic status correlates with expression and has prognostic significance in patients with MYC/BCL2 protein double-positive diffuse large B-cell lymphoma. Am J Surg Pathol. 2015 Sep;39(9):1250-8. doi: 10.1097/PAS.0000000000000433. PMID: 25828389
Li S, Weiss VL, Wang XJ, Desai PA, Hu S, Yin CC, Tang G, Reddy NM, Medeiros LJ, Lin P. High-grade B-cell lymphoma with MYC rearrangement and without BCL2 and BCL6 rearrangements is associated with high TP53 expression and a poor prognosis. Am J Surg Pathol. 2016 Feb;40(2):253-61. doi: 10.1097/PAS.0000000000000542. PMID: 26448193
Liu W, Hu S, Konopleva M, Khoury JD, Kalhor N, Tang G, Bueso-Ramos CE, Jorgensen JL, Lin P, Medeiros LJ, Lu X. De Novo MYC and BCL2 Double-hit B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in Pediatric and Young Adult Patients Associated With Poor Prognosis. Pediatr Hematol Oncol. 2015 Nov;32(8):535-47. doi: 10.3109/08880018.2015.1087611. PMID: 26558423
Ye Q, Xu-Monette ZY, Tzankov A, Deng L, Wang X, Manyam GC, Visco C, Montes-Moreno S, Zhang L, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WWL, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Parsons BM, Møller MB, Piris MA, Winter JN, Medeiros LJ, Hu S, Young KH. Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma. Oncotarget. 2016 Jan 19;7(3):2401-16. doi: 10.18632/oncotarget.6262. PMID: 26573234
Miao Y, Hu S, Lu X, Li S, Wang W, Medeiros LJ, Lin P. Double-hit follicular lymphoma with MYC and BCL2 translocations: A study of 7 Cases with a review of Literature. Hum Pathol. 2016 Aug 17. pii: S0046-8177(16)30179-4. doi: 10.1016/j.humpath.2016.07.025. PMID: 27544800
Boddu PC, Wang S, Pemmaraju N, Tang Z, Hu S, Li S, Xu J, Medeiros LJ, Tang G. 8q24/MYC rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms. Leuk Res. 2018 Feb 2;66:73-78. doi: 10.1016/j.leukres.2018.01.013. PMID: 29407586
Tang G, Li S, Toruner GA, Jain P, Tang Z, Hu S, Xu J, Cheng J, Robinson M, Vega F, Medeiros LJ. Clinical impact of 5’ MYC or 3’ MYC gain/loss detected by FISH in patients with aggressive B-cell lymphomas. Cancer Genet. 2023 Apr;272-273:1-8. doi: 10.1016/j.cancergen.2022.12.001. PMID: 36566629.
Plenary Paper. CME article. CME Questions. Blood. 2013 May121:4250
Chen Z, Hu S. MYC/BCL2 double-hit lymphoma mimicking acute leukemia at initial presentation. Blood. 2016 Feb 25;127(8):1072. doi: 10.1182/blood-2015-11-683730. PMID: 27351033
Hu Z, Medeiros LJ, Chen Z, Chen W, Li S, Konoplev SN, Lu X, Lan V Pham, Young KH, Wang W, Hu S. Mantle cell lymphoma with MYC rearrangement: A report of 17 patients. Am J Surg Pathol. 2017 Feb;41(2):216-224. doi: 10.1097/PAS.0000000000000758. PMID: 27776009
Liu H, Xu-Monette Z, Tang G, Wang W, Kim Y, Yuan J, Chen W, Li Y, Li Y, Zhu F, Fang X, Luedke C, Medeiros LJ, Young KH, Hu S. EBV-positive high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study. Histopathology. 2022 Feb;80(3):575-588. doi: 10.1111/his.14585. PMID: 34637146.
Liu H, Shen Q, Chang CC, Hu S. Phenotypic switch in high-grade B-cell lymphoma with MYC and BCL6 rearrangements: a potential mechanism of therapeutic resistance in lymphoma? Front Oncol. 2021 Dec 23;11:795330. doi: 10.3389/fonc.2021.795330. eCollection 2021. PMID: 35004320
Wang X, Tang G, Hu Z, Fang H, Wang W, Tang Z, Toruner GA, Zhou T, DiNardo CD, Garcia-Manero G, Verstovsek S, Bueso-Ramos CE, Medeiros LJ, Hu S. Myeloid neoplasms with 8q24/MYC rearrangement are frequently associated with myelodysplasia, complex karyotype, TP53 alterations, and inferior survival. Br J Haematol. 2022 Aug;198(3):604-608. doi: 10.1111/bjh.18278. PMID: 35645146.
Li Y, Hu S, Wang SA, Li S, Huh YO, Tang Z, Medeiros LJ, Tang G. The clinical significance of 8q245/MYC rearrangement in chronic lymphocytic leukemia. Mod Pathol. 2016 May;29(5):444-451. doi: 10.1038/modpathol.2016.35. PMID: 26916070
Wang W, Hu S, Lu X, Young KH, Medeiros LJ. Triple-hit B-cell lymphomas with MYC, BCL2 and BCL6 translocations/rearrangements: clinicopathologic features of 11 cases. Am J Surg Pathol. 2015 Aug;39(8):1132-9. doi: 10.1097/PAS.0000000000000434. PMID: 25828391
Wang X, Medeiros LJ, Lin P, Yin CC, Hu S, Thompson MA, Li S. MYC cytogenetic status correlates with expression and has prognostic significance in patients with MYC/BCL2 protein double-positive diffuse large B-cell lymphoma. Am J Surg Pathol. 2015 Sep;39(9):1250-8. doi: 10.1097/PAS.0000000000000433. PMID: 25828389
Li S, Weiss VL, Wang XJ, Desai PA, Hu S, Yin CC, Tang G, Reddy NM, Medeiros LJ, Lin P. High-grade B-cell lymphoma with MYC rearrangement and without BCL2 and BCL6 rearrangements is associated with high TP53 expression and a poor prognosis. Am J Surg Pathol. 2016 Feb;40(2):253-61. doi: 10.1097/PAS.0000000000000542. PMID: 26448193
Liu W, Hu S, Konopleva M, Khoury JD, Kalhor N, Tang G, Bueso-Ramos CE, Jorgensen JL, Lin P, Medeiros LJ, Lu X. De Novo MYC and BCL2 Double-hit B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in Pediatric and Young Adult Patients Associated With Poor Prognosis. Pediatr Hematol Oncol. 2015 Nov;32(8):535-47. doi: 10.3109/08880018.2015.1087611. PMID: 26558423
Ye Q, Xu-Monette ZY, Tzankov A, Deng L, Wang X, Manyam GC, Visco C, Montes-Moreno S, Zhang L, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WWL, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Parsons BM, Møller MB, Piris MA, Winter JN, Medeiros LJ, Hu S, Young KH. Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma. Oncotarget. 2016 Jan 19;7(3):2401-16. doi: 10.18632/oncotarget.6262. PMID: 26573234
Miao Y, Hu S, Lu X, Li S, Wang W, Medeiros LJ, Lin P. Double-hit follicular lymphoma with MYC and BCL2 translocations: A study of 7 Cases with a review of Literature. Hum Pathol. 2016 Aug 17. pii: S0046-8177(16)30179-4. doi: 10.1016/j.humpath.2016.07.025. PMID: 27544800
Boddu PC, Wang S, Pemmaraju N, Tang Z, Hu S, Li S, Xu J, Medeiros LJ, Tang G. 8q24/MYC rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms. Leuk Res. 2018 Feb 2;66:73-78. doi: 10.1016/j.leukres.2018.01.013. PMID: 29407586
Tang G, Li S, Toruner GA, Jain P, Tang Z, Hu S, Xu J, Cheng J, Robinson M, Vega F, Medeiros LJ. Clinical impact of 5’ MYC or 3’ MYC gain/loss detected by FISH in patients with aggressive B-cell lymphomas. Cancer Genet. 2023 Apr;272-273:1-8. doi: 10.1016/j.cancergen.2022.12.001. PMID: 36566629.