CML & BCR-ABL1
Wang W, Cortes JE, Lin P, Beaty MW, Ai D, Amin HA, McDonenell TJ, Ok CY, Kantarjian HM, Medeiros LJ, Hu S. Clinical and prognostic significance of 3q26.2 rearrangements and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors. Blood. 2015 Oct 1;126(14):1699-706. doi: 10.1182/blood-2015- 05-646489. PMID: 26243778
Highlighted by MDedge Hematology News: Chromosome 3 abnormalities linked to poor CML outcomes
Highlighted by News Medical: Chromosome 3q26.2 rearrangements linked to poor CML prognosis
Wang W, Cortes JE, Tang G, Khoury JD, Wang S, Bueso-Ramos CE, DiGiuseppe JA, Chen Z, Kantarjian KM, Medeiros LJ, Hu S. Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood. 2016 Jun 2;127(22):2742-2750. doi: 10.1182/blood-2016- 01-690230. PMID: 27006386
Highlighted in this issue. *Commentary by François Guilhot. Cytogenetics in CML: more important than you think. Blood. 2016 Jun 2;127(22):2661-2662
Highlighted by iCMLf in Latest advances from key CML publications: Additional chromosomal abnormalities prognostic for CML
Zheng L, Hu S. Philadelphia chromosome-positive B-lymphoblastic lymphoma involves genitourinary system and bone at initial diagnosis and at relapse. Blood. 2017 Sep 21;130(12):1483. doi: 10.1182/blood-2017-05-785626. PMID: 28935645
Wang W, Cortes JE, Lin P, Khoury JD, Ai D, Tang Z, Tang G, Jorgensen JL, Medeiros LJ, Hu S. Impact of trisomy 8 on treatment response and survival of patients with chronic myelogenous leukemia in era of tyrosine kinase inhibitors. Leukemia. 2015 Nov;29(11):2263-6. doi: 10.1038/leu.2015.96. PMID: 25931274
Chen Z, Cortes JE, Jorgensen JL, Wang W, Yin CC, You MJ, Jabbour E, Kantarjian HM, Medeiros LJ, Hu S. Differential impact of additional chromosomal abnormalities in myeloid vs lymphoid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Leukemia. 2016 Jul;30(7):1606-1609. doi: 10.1038/leu.2016.6. PMID: 26837843
Chen Z, Chen S, Wang W, Zuo Z, Mou X, Hu SJ, DiGiuseppe JA, Zu Y, Medeiros LJ, Hu S. Cytogenetic landscape and impact in blast phase of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Leukemia. 2017 Mar:31(3):585-592. doi: 10.1038/leu.2016.231. PMID: 27560111
Faculty spotlight by MD Anderson Cancer Center
Highlighted by iCMLf in Latest advances from key CML publications: ACAs characterised for blast phase–CML after TKI therapy
Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng W, Choi JK, Colmenero I, Coupland SE, Cross NCP, De Jong D, Elghetany MT, Takahashi E, Emile J, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, C Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li X, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A. The 5th Edition of The World Health Organization Classification of Haematolymphoid Tumors: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. PMID: 35732831.
Gong Z, Medeiros LJ, Cortes JE, Chen Z, Zheng L, Li Y, Bai S, Lin P, Miranda RN, Jorgensen LJ, McDonnell TJ, Wang W, Kantarjian H, Hu S. Cytogenetics-based risk prediction of blastic transformation of CML treated with tyrosine kinase inhibitors. Blood Adv. 2017 Dec 12;1(26):2541-2552. PMID: 29296906
Highlighted by NCCN: Chromosomal Alterations in Predicting Blastic Transformation in CML
Chen Z, Medeiros LJ, Kantarjian HM, Zheng L, Gong Z, Patel KP, Xiong H, Wang W, Cortes JE, Hu S. Differential depth of treatment response required for optimal outcome in blast phase versus chronic phase of chronic myeloid leukemia. Blood Cancer J. 2017 Feb 3;7(2):e521. doi: 10.1038/bcj.2017.4. PMID: 28157214
Chen Z, Wang W, Cortes JE, Liu E, Miranda RN, Zhao C, Yuan J, Lu, X, Yang W, Dadfarnia M, Kantarjian HM, Medeiros LJ, Hu S. Differential clinical and prognostic impact of myeloid sarcoma versus medullary myeloid blast phase in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood Cancer J. 2016 May 6;6:e418. doi: 10. 1038/bcj.2016.27. PMID: 27152845
Gong Z, Medeiros LJ, Cortes JE, Zheng L, Khoury JD, Wang W, Tang G, Loghavi S, Luthra R, Yang W, Kantarjian H, Hu S. Clinical and prognostic significance of e1a2 BCR-ABL1 transcript subtype in chronic myeloid leukemia. Blood Cancer J. 2017 Jul 14;7(7):e583. doi: 10.1038/bcj.2017.62. PMID: 28708130
Wang W, Chen Z, Hu Z, Yin CC, Li S, Bai S, Bueso-Ramos CE, Medeiros LJ, Hu S. Clinical significance of trisomy 8 that emerges during therapy in chronic myeloid leukemia. Blood Cancer J. 2016 Nov 4;6(11):e490. doi: 10.1038/bcj.2016.96. PMID: 27813536
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S. Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome. Mod Pathol 2018 Jul;31(7):1141-1154. doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Tang Z, Toruner GA, Tang G, Yin CC, Wang W, Hu S, Thakral B, Wang SA, Miranda RN, Khoury JD, Medeiros LJ. Chronic myeloid leukemia with insertion-derived BCR-ABL1 fusion: redefining complex chromosomal abnormalities by correlating FISH and karyotype studies predicts prognosis. Mod Pathol. 2020 Oct;33(10):2035-2045. doi: 10.1038/s41379-020-0564-6. PMID: 32404952
Rivera D, Cui W, Gao J, Peker D, Zhang Q, Dewar R, Qiu L, Konoplev S, Hu Z, Sasaki K, Hu AY, E S, Liu M, Fang H, Wang W, Tang G, Apperley JF, Hochhaus A, Cortes JE, Khoury JD, Medeiros LJ, Jabbour E, Hu S. Aleukemic chronic myeloid leukemia without leukocytosis and thrombocytosis: a report from the BCR::ABL1 Pathology Group. Mod Pathol 2024 Feb;37(2):100406. doi: 10.1016/j.modpat.2023.100406. PMID: 38104892.
Wang W, Tang G, Cortes JE, Liu H, Ai D, Yin CC, Li S, Khoury JD, Bueso-Ramos CE, Medeiros LJ, Hu S. Chromosomal rearrangements involving 11q23/MLL in chronic myelogenous leukemia: a rare phenomenon frequently associated with disease progression and poor prognosis. J Hematol Oncol. 2015 Apr 8:8:32. doi:10.1186/s13045-015-0128-2. PMID: 25888368
Chen Z, Wang W, Rich A, Tang G, Hu S. Myeloid sarcoma as the initial presentation of chronic myelogenous leukemia, medullary chronic phase in era of tyrosine kinase inhibitors: a report of 11 cases. Am J Hematol 2015 Aug;90(8):E146-8. doi: 10.1002/ajh.24045. PMID: 25960187
Gong Z, Xu ML, Chen M, Cui W, Kantarjian HM, Cortes JE, Zhou T, Tang G, Wang W, Medeiros LJ, Hu S. Philadelphia chromosome-negative acute leukemia in patients with chronic myeloid leukemia. Am J Hematol. 2019 Oct;94(10):E256-E259. doi: 10.1002/ajh.25571. PMID: 31273842
Salem A, Loghavi S, Tang G, Huh YO, Jabbour EJ, Kantarjian H, Wang W, Hu S, Luthra R, Medeiros LJ, Khoury J. Myeloid neoplasms with concurrent BCR-ABL1 and CBFB rearrangements: a series of 10 cases of a clinically aggressive neoplasm. Am J Hematol. 2017 Jun;92(6):520-528. doi: 10.1002/ajh.24710. PMID: 28253536
Hu S, Jabbour EJ, Hu CY, Tang G, Wang W, Medeiros LJ, Bueso-Ramos C. Recurrent lymphoid and myeloid relapses due to treatment cessations reveal natural history of Ph-positive B-ALL and poses a diagnostic challenge. Am J Hematol. 2024 Apr;99(4):721-726. doi: 10.1002/ajh.27210. PMID: 38240333.
Gong Z, Zhou T, Liu H, Tang G, Yin CC, Wang W, Medeiros LJ, Hu S. Genotype-phenotype correlation of unusual BCR-ABL1 transcripts in Philadelphia chromosome-positive leukemia. Br J Haematol. 2020 Jun;189(5): e207-e211. doi: 10.1111/bjh.16627
Bai S, Hu S. BCR-ABL1-negative acute myeloid leukemia relapsing as BCR-ABL1-positive disease. Br J Hematol. 2017 Feb;176(4):514. doi: 10.1111/bjh.14484. PMID: 27982417
Wang W, Ali S, Tang Z, Miranda RN, Medeiros LJ, Hu S. Constitutional pericentric inversion of chromosome 9 has no impact on survival in chronic myelogenous leukemia. Ann Hematol 2016 Mar;95(4):657-9. doi: 10.1007/s00277-016-2592-3. PMID: 26758271
Gong Z, Zheng L, Tang Z, Chen Z, Wang W, Bai S, Tang G, Medeiros LJ, Hu S. Role of complexity of variant Philadelphia chromosome in chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Ann Hematol. 2017 Mar;96(3):501-504. doi: 10.1007/s00277-016-2892-7. PMID: 27915425
Gong Z, Xie W, Wang W, Chen Z, Xue J, Yuan J, Zhou Y, Wang D, Medeiros LJ, Hu S. T-lymphoid or T/myeloid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Int J Lab Hematol. 2017 Apr;39(2):e45-e50. doi: 10.1111/ijlh.12605. PMID: 27863007
Chen Z, Wang W, Verstovsek S, Cortes JE, Medeiros LJ, Hu S. Chronic myelogenous leukemia in patients with MPL or JAK2 mutation-positive myeloproliferative neoplasm. Int J Lab Hematol. 2015 Dec;37(6):e150-2. doi: 10.1111/ijlh.12398. PMID: 26086872
Hu Z, Singhi E, Apostolidou E, Mai B, Juneja HS, Hu S. Mass-forming neoplastic extramedullary hematopoiesis mimics myeloid sarcoma in a patient with chronic phase chronic myeloid leukemia. Int J Lab Hematol. 2021 Jun;43(3):e135-e137. doi: 10.1111/ijlh.13432. PMID: 33314782.
Jaitly V, Wang W, Hu S. Philadelphia chromosome-negative acute myeloid leukemia with 11q23/MLL translocation in a patient with chronic myelogenous leukemia. Stem Cell Investig. 2015 Jul 1;2:13. doi: 10.3978/j.issn.2306-9759.2015.06.01. PMID: 27358881
Gong Z, Wang W, Hu S. Cytogenetics alterations in CML: not all created equal. Oncotarget 2018 Feb 10;9(15):11885-11886. doi: 10.18632/oncotarget.24471. PMID: 29552278
Zhou T, Medeiros LJ, Hu S. Chronic myeloid leukemia: beyond BCR-ABL1. Curr Hematol Malig Rep. 2018 Dec;13(6):435-445. doi: 10.1007/s11899-018-0474-6. PMID: 30370478
Zhou T, Hu S. Chronic Myeloid Leukemia. In: Wang E, Lagoo AS, eds. Manual of Lymph Node and Bone Marrow Pathology: Frequently Asked Questions. Springer; 1st ed. 2020 edition (March 28, 2020)
Hidalgo-Lopez JE, Quesada AE, Kanagal-Shamanna R, Gong Z, Wang W, Hu S, Medeiros LJ, Bassett RL, d’Orcy E, Yin CC, Cortes JE, Jabbour E, Kantarjian HM, Bueso-Ramos C. Diagnostic utility of bone marrow core biopsy in chronic myeloid leukemia. Cancer 2018 Oct 1;124(19):3849-3855. doi: 10.1002/cncr.31663. PMID: 30321462
Xie W, Wang SA, Hu S, Xu J, Medeiros LJ, Tang G. Myeloproliferative neoplasm with ABL1/EVT6 rearrangement mimics chronic myeloid leukemia and responses to tyrosine kinase inhibitors. Cancer Genetics 2018 Dec 1;228:41-46. PMID: 30553471
Chen Z, Hu S, Wang SA, Konopleva M, Tang Z, Xu J, Li S, Toruner G, Thakral B, Medeiros LJ, Tang G. Chronic myeloid leukemia presenting in lymphoblastic crisis, a differential diagnosis with Philadelphia chromosome-positive B-lymphoblastic leukemia. Leuk Lymphoma. 2020 Dec;61(12):2831-2838. doi: 10.1080/10428194.2020.1795160. PMID: 32700989.
Morita K, Jabbour E, Ravandi F, Borthakur G, Khoury JD, Hu S, Garcia-Manero G, Wierda W, Issa G, Daver N, Pemmaraju N, Montalban-Bravo G, Soltysiak KA, Pierce S, Bueso-Ramos CE, Cortes J, Sasaki K. Clinical outcomes of patients with chronic myeloid leukemia with concurrent core binding factor rearrangement and Philadelphia chromosome. Clin Lymphoma Myeloma Leuk. 2021 May;21(5):338-344. doi: 10.1016/j.clml.2020.12.025. PMID: 33597098.
Young PE, Kanagal Shamanna R, Hu S, Tang G, Thakral B, Daver N, Issa GC, Medeiros LJ, Konoplev S. Chronic myeloid leukemia, BCR-ABL1-positive, carrying NPM1 mutation: first case series from a single institution. Leuk Res. 2021. Dec;111:106685. doi: 10.1016/j.leukres.2021.106685. PMID: 34438119.
Highlighted by MDedge Hematology News: Chromosome 3 abnormalities linked to poor CML outcomes
Highlighted by News Medical: Chromosome 3q26.2 rearrangements linked to poor CML prognosis
Wang W, Cortes JE, Tang G, Khoury JD, Wang S, Bueso-Ramos CE, DiGiuseppe JA, Chen Z, Kantarjian KM, Medeiros LJ, Hu S. Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood. 2016 Jun 2;127(22):2742-2750. doi: 10.1182/blood-2016- 01-690230. PMID: 27006386
Highlighted in this issue. *Commentary by François Guilhot. Cytogenetics in CML: more important than you think. Blood. 2016 Jun 2;127(22):2661-2662
Highlighted by iCMLf in Latest advances from key CML publications: Additional chromosomal abnormalities prognostic for CML
Zheng L, Hu S. Philadelphia chromosome-positive B-lymphoblastic lymphoma involves genitourinary system and bone at initial diagnosis and at relapse. Blood. 2017 Sep 21;130(12):1483. doi: 10.1182/blood-2017-05-785626. PMID: 28935645
Wang W, Cortes JE, Lin P, Khoury JD, Ai D, Tang Z, Tang G, Jorgensen JL, Medeiros LJ, Hu S. Impact of trisomy 8 on treatment response and survival of patients with chronic myelogenous leukemia in era of tyrosine kinase inhibitors. Leukemia. 2015 Nov;29(11):2263-6. doi: 10.1038/leu.2015.96. PMID: 25931274
Chen Z, Cortes JE, Jorgensen JL, Wang W, Yin CC, You MJ, Jabbour E, Kantarjian HM, Medeiros LJ, Hu S. Differential impact of additional chromosomal abnormalities in myeloid vs lymphoid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Leukemia. 2016 Jul;30(7):1606-1609. doi: 10.1038/leu.2016.6. PMID: 26837843
Chen Z, Chen S, Wang W, Zuo Z, Mou X, Hu SJ, DiGiuseppe JA, Zu Y, Medeiros LJ, Hu S. Cytogenetic landscape and impact in blast phase of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Leukemia. 2017 Mar:31(3):585-592. doi: 10.1038/leu.2016.231. PMID: 27560111
Faculty spotlight by MD Anderson Cancer Center
Highlighted by iCMLf in Latest advances from key CML publications: ACAs characterised for blast phase–CML after TKI therapy
Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng W, Choi JK, Colmenero I, Coupland SE, Cross NCP, De Jong D, Elghetany MT, Takahashi E, Emile J, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, C Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li X, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A. The 5th Edition of The World Health Organization Classification of Haematolymphoid Tumors: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. PMID: 35732831.
Gong Z, Medeiros LJ, Cortes JE, Chen Z, Zheng L, Li Y, Bai S, Lin P, Miranda RN, Jorgensen LJ, McDonnell TJ, Wang W, Kantarjian H, Hu S. Cytogenetics-based risk prediction of blastic transformation of CML treated with tyrosine kinase inhibitors. Blood Adv. 2017 Dec 12;1(26):2541-2552. PMID: 29296906
Highlighted by NCCN: Chromosomal Alterations in Predicting Blastic Transformation in CML
Chen Z, Medeiros LJ, Kantarjian HM, Zheng L, Gong Z, Patel KP, Xiong H, Wang W, Cortes JE, Hu S. Differential depth of treatment response required for optimal outcome in blast phase versus chronic phase of chronic myeloid leukemia. Blood Cancer J. 2017 Feb 3;7(2):e521. doi: 10.1038/bcj.2017.4. PMID: 28157214
Chen Z, Wang W, Cortes JE, Liu E, Miranda RN, Zhao C, Yuan J, Lu, X, Yang W, Dadfarnia M, Kantarjian HM, Medeiros LJ, Hu S. Differential clinical and prognostic impact of myeloid sarcoma versus medullary myeloid blast phase in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood Cancer J. 2016 May 6;6:e418. doi: 10. 1038/bcj.2016.27. PMID: 27152845
Gong Z, Medeiros LJ, Cortes JE, Zheng L, Khoury JD, Wang W, Tang G, Loghavi S, Luthra R, Yang W, Kantarjian H, Hu S. Clinical and prognostic significance of e1a2 BCR-ABL1 transcript subtype in chronic myeloid leukemia. Blood Cancer J. 2017 Jul 14;7(7):e583. doi: 10.1038/bcj.2017.62. PMID: 28708130
Wang W, Chen Z, Hu Z, Yin CC, Li S, Bai S, Bueso-Ramos CE, Medeiros LJ, Hu S. Clinical significance of trisomy 8 that emerges during therapy in chronic myeloid leukemia. Blood Cancer J. 2016 Nov 4;6(11):e490. doi: 10.1038/bcj.2016.96. PMID: 27813536
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S. Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome. Mod Pathol 2018 Jul;31(7):1141-1154. doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Tang Z, Toruner GA, Tang G, Yin CC, Wang W, Hu S, Thakral B, Wang SA, Miranda RN, Khoury JD, Medeiros LJ. Chronic myeloid leukemia with insertion-derived BCR-ABL1 fusion: redefining complex chromosomal abnormalities by correlating FISH and karyotype studies predicts prognosis. Mod Pathol. 2020 Oct;33(10):2035-2045. doi: 10.1038/s41379-020-0564-6. PMID: 32404952
Rivera D, Cui W, Gao J, Peker D, Zhang Q, Dewar R, Qiu L, Konoplev S, Hu Z, Sasaki K, Hu AY, E S, Liu M, Fang H, Wang W, Tang G, Apperley JF, Hochhaus A, Cortes JE, Khoury JD, Medeiros LJ, Jabbour E, Hu S. Aleukemic chronic myeloid leukemia without leukocytosis and thrombocytosis: a report from the BCR::ABL1 Pathology Group. Mod Pathol 2024 Feb;37(2):100406. doi: 10.1016/j.modpat.2023.100406. PMID: 38104892.
Wang W, Tang G, Cortes JE, Liu H, Ai D, Yin CC, Li S, Khoury JD, Bueso-Ramos CE, Medeiros LJ, Hu S. Chromosomal rearrangements involving 11q23/MLL in chronic myelogenous leukemia: a rare phenomenon frequently associated with disease progression and poor prognosis. J Hematol Oncol. 2015 Apr 8:8:32. doi:10.1186/s13045-015-0128-2. PMID: 25888368
Chen Z, Wang W, Rich A, Tang G, Hu S. Myeloid sarcoma as the initial presentation of chronic myelogenous leukemia, medullary chronic phase in era of tyrosine kinase inhibitors: a report of 11 cases. Am J Hematol 2015 Aug;90(8):E146-8. doi: 10.1002/ajh.24045. PMID: 25960187
Gong Z, Xu ML, Chen M, Cui W, Kantarjian HM, Cortes JE, Zhou T, Tang G, Wang W, Medeiros LJ, Hu S. Philadelphia chromosome-negative acute leukemia in patients with chronic myeloid leukemia. Am J Hematol. 2019 Oct;94(10):E256-E259. doi: 10.1002/ajh.25571. PMID: 31273842
Salem A, Loghavi S, Tang G, Huh YO, Jabbour EJ, Kantarjian H, Wang W, Hu S, Luthra R, Medeiros LJ, Khoury J. Myeloid neoplasms with concurrent BCR-ABL1 and CBFB rearrangements: a series of 10 cases of a clinically aggressive neoplasm. Am J Hematol. 2017 Jun;92(6):520-528. doi: 10.1002/ajh.24710. PMID: 28253536
Hu S, Jabbour EJ, Hu CY, Tang G, Wang W, Medeiros LJ, Bueso-Ramos C. Recurrent lymphoid and myeloid relapses due to treatment cessations reveal natural history of Ph-positive B-ALL and poses a diagnostic challenge. Am J Hematol. 2024 Apr;99(4):721-726. doi: 10.1002/ajh.27210. PMID: 38240333.
Gong Z, Zhou T, Liu H, Tang G, Yin CC, Wang W, Medeiros LJ, Hu S. Genotype-phenotype correlation of unusual BCR-ABL1 transcripts in Philadelphia chromosome-positive leukemia. Br J Haematol. 2020 Jun;189(5): e207-e211. doi: 10.1111/bjh.16627
Bai S, Hu S. BCR-ABL1-negative acute myeloid leukemia relapsing as BCR-ABL1-positive disease. Br J Hematol. 2017 Feb;176(4):514. doi: 10.1111/bjh.14484. PMID: 27982417
Wang W, Ali S, Tang Z, Miranda RN, Medeiros LJ, Hu S. Constitutional pericentric inversion of chromosome 9 has no impact on survival in chronic myelogenous leukemia. Ann Hematol 2016 Mar;95(4):657-9. doi: 10.1007/s00277-016-2592-3. PMID: 26758271
Gong Z, Zheng L, Tang Z, Chen Z, Wang W, Bai S, Tang G, Medeiros LJ, Hu S. Role of complexity of variant Philadelphia chromosome in chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Ann Hematol. 2017 Mar;96(3):501-504. doi: 10.1007/s00277-016-2892-7. PMID: 27915425
Gong Z, Xie W, Wang W, Chen Z, Xue J, Yuan J, Zhou Y, Wang D, Medeiros LJ, Hu S. T-lymphoid or T/myeloid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Int J Lab Hematol. 2017 Apr;39(2):e45-e50. doi: 10.1111/ijlh.12605. PMID: 27863007
Chen Z, Wang W, Verstovsek S, Cortes JE, Medeiros LJ, Hu S. Chronic myelogenous leukemia in patients with MPL or JAK2 mutation-positive myeloproliferative neoplasm. Int J Lab Hematol. 2015 Dec;37(6):e150-2. doi: 10.1111/ijlh.12398. PMID: 26086872
Hu Z, Singhi E, Apostolidou E, Mai B, Juneja HS, Hu S. Mass-forming neoplastic extramedullary hematopoiesis mimics myeloid sarcoma in a patient with chronic phase chronic myeloid leukemia. Int J Lab Hematol. 2021 Jun;43(3):e135-e137. doi: 10.1111/ijlh.13432. PMID: 33314782.
Jaitly V, Wang W, Hu S. Philadelphia chromosome-negative acute myeloid leukemia with 11q23/MLL translocation in a patient with chronic myelogenous leukemia. Stem Cell Investig. 2015 Jul 1;2:13. doi: 10.3978/j.issn.2306-9759.2015.06.01. PMID: 27358881
Gong Z, Wang W, Hu S. Cytogenetics alterations in CML: not all created equal. Oncotarget 2018 Feb 10;9(15):11885-11886. doi: 10.18632/oncotarget.24471. PMID: 29552278
Zhou T, Medeiros LJ, Hu S. Chronic myeloid leukemia: beyond BCR-ABL1. Curr Hematol Malig Rep. 2018 Dec;13(6):435-445. doi: 10.1007/s11899-018-0474-6. PMID: 30370478
Zhou T, Hu S. Chronic Myeloid Leukemia. In: Wang E, Lagoo AS, eds. Manual of Lymph Node and Bone Marrow Pathology: Frequently Asked Questions. Springer; 1st ed. 2020 edition (March 28, 2020)
Hidalgo-Lopez JE, Quesada AE, Kanagal-Shamanna R, Gong Z, Wang W, Hu S, Medeiros LJ, Bassett RL, d’Orcy E, Yin CC, Cortes JE, Jabbour E, Kantarjian HM, Bueso-Ramos C. Diagnostic utility of bone marrow core biopsy in chronic myeloid leukemia. Cancer 2018 Oct 1;124(19):3849-3855. doi: 10.1002/cncr.31663. PMID: 30321462
Xie W, Wang SA, Hu S, Xu J, Medeiros LJ, Tang G. Myeloproliferative neoplasm with ABL1/EVT6 rearrangement mimics chronic myeloid leukemia and responses to tyrosine kinase inhibitors. Cancer Genetics 2018 Dec 1;228:41-46. PMID: 30553471
Chen Z, Hu S, Wang SA, Konopleva M, Tang Z, Xu J, Li S, Toruner G, Thakral B, Medeiros LJ, Tang G. Chronic myeloid leukemia presenting in lymphoblastic crisis, a differential diagnosis with Philadelphia chromosome-positive B-lymphoblastic leukemia. Leuk Lymphoma. 2020 Dec;61(12):2831-2838. doi: 10.1080/10428194.2020.1795160. PMID: 32700989.
Morita K, Jabbour E, Ravandi F, Borthakur G, Khoury JD, Hu S, Garcia-Manero G, Wierda W, Issa G, Daver N, Pemmaraju N, Montalban-Bravo G, Soltysiak KA, Pierce S, Bueso-Ramos CE, Cortes J, Sasaki K. Clinical outcomes of patients with chronic myeloid leukemia with concurrent core binding factor rearrangement and Philadelphia chromosome. Clin Lymphoma Myeloma Leuk. 2021 May;21(5):338-344. doi: 10.1016/j.clml.2020.12.025. PMID: 33597098.
Young PE, Kanagal Shamanna R, Hu S, Tang G, Thakral B, Daver N, Issa GC, Medeiros LJ, Konoplev S. Chronic myeloid leukemia, BCR-ABL1-positive, carrying NPM1 mutation: first case series from a single institution. Leuk Res. 2021. Dec;111:106685. doi: 10.1016/j.leukres.2021.106685. PMID: 34438119.