AML and MDS
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S. Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome. Mod Pathol 2018 Jul;31(7):1141-1154. doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Fang H, Yabe M, Zhang X, Kim Y, Wu X, Wei P, Chi S, Zheng L, Garcia-Manero G, Shao L, Yuan J, Shen Y, Zheng G, Tang G, Wang W, Loghavi S, Shen Q, Yuan Y, He R, Chen D, Medeiros LJ, Hu S. Myelodysplastic syndrome with t(6;9)(p22;q34.1)/DEK-NUP214 better classified as acute myeloid leukemia? A multicenter study of 107 cases. Mod Pathol. 2021 Jun;34(6):1143-1152. doi: 10.1038/s41379-021-00741-w. PMID: 33558656.
Wang X, Tang G, Hu Z, Fang H, Wang W, Tang Z, Toruner GA, Zhou T, DiNardo CD, Garcia-Manero G, Verstovsek S, Bueso-Ramos CE, Medeiros LJ, Hu S. Myeloid neoplasms with 8q24/MYC rearrangement are frequently associated with myelodysplasia, complex karyotype, TP53 alterations, and inferior survival. Br J Haematol. 2022 Aug;198(3):604-608. doi: 10.1111/bjh.18278. PMID: 35645146.
Zhou T, Curry CV, Khanlari M, Shi M, Cui W, Peker D, Chen W, Wang E, Gao J, Shen Q, Xie W, Jelloul FZ, King RL, Yuan J, Wang X, Zhao C, Obiorah IE, Courville EL, Normura E, Cherian S, Xu ML, Burack WR, Liu HX, Jabbour EJ, Takahashi K, Wang W, Wang SA, Khoury JD, Medeiros LJ, Hu S. Genetics and pathologic landscape of lineage switch of acute leukemia during therapy. Blood Cancer J 2024 Jan 25;14(1):19. doi: 10.1038/s41408-024-00983-2. PMID: 38272888.
Liu H, Hu S. Acute leukemic variant of blastic plasmacytoid dendritic cell neoplasm at initial presentation. Blood. 2020 Apr 23;135(17):1506. doi: 10.1182/blood.2020005039. PMID: 32324873
Liu H, Miao Y, Ferrajoli A, Tang G, McDonnell T, Medeiros LJ, Hu S. Leukemic phase of Richter transformation: a mimic of acute myeloid leukemia that responded to ibrutinib monotherapy. Am J Hematol. 2020 Oct;95(10):1221-1223. doi: 10.1002/ajh.25782. PMID: 32162729
Gong Z, Xu ML, Chen M, Cui W, Kantarjian HM, Cortes JE, Zhou T, Tang G, Wang W, Medeiros LJ, Hu S. Philadelphia chromosome-negative acute leukemia in patients with chronic myeloid leukemia. Am J Hematol. 2019 Oct;94(10):E256-E259. doi: 10.1002/ajh.25571. PMID: 31273842
Xie W, Tang G, Wang E, Young K, Cloe A, Shen Q, Zhou Y, Garcia-Manero G, Loghav S, Hu AY, Wang SA, Bueso-Ramos C, Kantarjian HM, Medeiros LJ, Hu S. t(11;16)(q23;p13)/KMT2A-CREPBP in hematologic neoplasms: presumptive evidence of myelodysplasia or therapy-related neoplasms? Ann Hematol. 2020 Mar;99(3):487-500. doi: 10.1007/s00277-020-03909-7. PMID: 30759270
Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng W, Choi JK, Colmenero I, Coupland SE, Cross NCP, De Jong D, Elghetany MT, Takahashi E, Emile J, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, C Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li X, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A. The 5th Edition of The World Health Organization Classification of Haematolymphoid Tumors: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. PMID: 35732831.
Wang W, Beird H, Kroll CJ, Hu S, Bueso-Ramos CE, Fang H, Tang G, Tang Z, Wang F, Takahashi K, You MJ, Khoury JD, Medeiros LJ, and Futreal PA. t(6;14)(q25;q32) involves BCL11B and is highly associated with mixed phenotype acute leukemia, T/myeloid. Leukemia 2020 Sep;34(9):2509-2512. doi: 10.1038/s41375-020-0761-9. PMID: 32099038
Yang Y, Tang Z, Huang Y, Hu Q, Wang S, Ji J, Du Y, Yang C, Chen M, Hu S, Han B. Sirolimus versus cyclosporine A in patients with primary acquired pure red cell aplasia: a prospective cohort study. Blood Cancer J. 2023 May 10;13(1):74. doi: 10.1038/s41408-023-00845-3. PMID: 37160872
Ronaghy A, Hu S, Tang Z, Wang W, Tang G, Lohgavi S, Li S. Thakral B, Medeiros LJ, Muzzafar T. Myeloid neoplasms associated with t(3;12)(p26.2;p13) are clinical aggressive, show myelodysplasia, and frequently harbor chromosome 7 abnormalities. Mod Pathol. 2021 Feb;34(2):300-313. doi: 10.1038/s41379-020-00663-z. PMID: 33110238.
Zuo Z, Maiti S, Hu S, Loghavi S, Calin GA, Garcia-Manero G, Kantarjian HM, Medeiros LJ, Cooper L, Bueso-Ramos CE. Plasma circulating-microRNA profiles are useful for assessing prognosis in patients with cytogenetically normal myelodysplastic syndromes. Mod Pathol. 2015 Mar;28(3):373-82. doi: 10.1038/modpath.2014.108. PMID: 25216221
Xie W, Xu J, Hu S, Li S, Wang W, Yin CC, Toruner G, Tang Z, Medeiros LJ, Tang G. iAMP21 in acute myeloid leukemia is associated with complex karyotype, TP53 mutation, and dismal outcome. Mod Pathol. 2020 Jul;33(7):1389-1397. doi: 10.1038/s41379-020-0494-3. PMID: 32034282
Goswami RS, Wang SA, Tang Z, Li Y, Zuo W, Hu S, Li S, Medeiros LJ, Tang G. Newly emerged isolated del(7q) in patients with prior cytotoxic therapies may not always be associated with therapy-related myeloid neoplasm. Mod Pathol. 2016 Jul;29(7):727-734. doi: 10.1038/modpath. 2016.67. PMID: 27056073
Xie W, Hu S, Xue J, Chen Z, Medeiros LJ, Tang G. Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults. Ann Hematol. 2019 May;98(5):1149-1157. PMID: 29288910
Hu Z, Hu S, Ji C, Tang Z, Thakral B, Loghavi S, Medeiros LJ, Wang W. 3q26.2/EVI1 rearrangement in myelodysplastic/myeloproliferative neoplasms: an early event associated with a poor prognosis. Leuk Res. 2017 Dec 23;65:25-28. doi: 10.1016/j.leukres.2017.12.004. PMID: 29288910
Bai S, Hu S. BCR-ABL1-negative acute myeloid leukemia relapsing as BCR-ABL1-positive disease. Br J Hematol. 2017 Feb;176(4):514. doi: 10.1111/bjh.14484. PMID: 27982417
Chen F, Hu S, Ruan J, Chen M, Han B. Mutational landscape and its clinical significance in paroxysmal nocturnal hemoglobinuria. Blood Cancer J. 2021 Mar 16;11(3):58. doi: 10.1038/s41408-021-00451-1. PMID: 33727526
Loghavi S, Sui D, Wei P, Garcia-Manero G, Pierce S, Routbort MJ, Jabbour EJ, Pemmaraju N, Kanagal-Shamanna R, Gur HD, Hu S, Zuo Z, Medeiros LJ, Kantarjian HM, Khoury JD. Validation of WHO 2017 Chronic myelomonocytic leukemia categories. Blood Adv. 2018 Aug 14;2(15):1807-1816. doi: 10.1182/bloodadvances.2018019224. PMID: 30054307
Tang G, Zhang L, Fu B, Hu J, Lu X, Hu S, Patel A, Goswami M, Khoury JD, Garcia-Manero G, Medeiros LJ, Wang SA. Cytogenetic risk stratification of 417 patients with chronic myelomonocytic leukemia from a single institute. Am J Hematol. 2014 Aug;89(8):813-8. doi: 10.1002/ajh.23751. PMID: 24782398
Tang G, Fu B, Hu S, Lu X, Tang Z, Li S, Jabbar K, Khoury JD, Medeiros LJ, Wang SA. Prognostic impact of acquisition of cytogenetic abnormalities during the course of chronic myelomonocytic leukemia. Am J Hematol. 2015 Oct;90(10):882-7. doi: 10.1002/ajh.24108. PMID: 26148174
Wang SA, Jorgensen JL, Hu S, Jia F, Li S, Loghavi S, Ok CY, Thakral B, Xu J, Medeiros LJ, Wang W. Validation of a 12-color multicolor flow cytometry assay for acute myeloid leukemia minimal residual/measurable disease detection. Cytometry B Clin Cytom. 2023 Sep;104(5):356-366. doi: 10.1002/cyto.b.22140. PMID: 37605812
Salem A, Loghavi S, Tang G, Huh YO, Jabbour EJ, Kantarjian H, Wang W, Hu S, Luthra R, Medeiros LJ, Khoury J. Myeloid neoplasms with concurrent BCR-ABL1 and CBFB rearrangements: a series of 10 cases of a clinically aggressive neoplasm. Am J Hematol. 2017 Jun;92(6):520-528. doi: 10.1002/ajh.24710. 28253536
Abou Dalle I, Kantarjian H, Bannon SA, Kanagal Shamanna R, Routbort M, Patel KP, Hu S, Bhalla K, Garcia-Manero G, DiNardo CD. Successful lenalidomide treatment in high risk myelodysplastic syndrome with germline DDX41 mutation. Am J Hematol. 2020 Feb;95(2):227-229. doi: 10.1002/ajh.25610. PMID: 31400013
El Hussein S, Hu S, Fang H, Garces S, Muzzafar T, Wang SA, Medeiros LJ, Bueso-Ramos CE, Jelloul FZ. Well-differentiated systemic mastocytosis with associated myeloid sarcoma and myelodysplastic syndrome: diagnostic challenges of an under-recognized entity. Leuk Lymphoma. 2022 Jan;63(1):235-238. doi: 10.1080/10428194.2021.1978089. PMID: 34510998.
Boddu PC, Wang S, Pemmaraju N, Tang Z, Hu S, Li S, Xu J, Medeiros LJ, Tang G. 8q24/MYC rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms. Leuk Res. 2018 Mar;66:73-78. doi: 10.1016/j.leukres.2018.01.013. PMID: 29407586
Tang Z, Li Y, Wang W, Yin CC, Tang G, Aung PP, Hu S, Lu X, Toruner GA, Medeiros LJ, Khoury JD. Genomic alterations involving 12p/ETV6 are highly prevalent in blastic plasmacytoid dendritic cell neoplasms and might represent early clonal events. Leuk Res 2018 Oct; 73: 86-94. doi: 10.1016/j.leukres.2018.09.006. PMID: 30248580
Tang Z, Li Y, Wang SA, Hu S, Li S, Lu X, Khoury JD, Medeiros LJ, Tang G. Clinical significance of acquired loss of X chromosome in bone marrow. Leuk Res. 2016 May 27;47:109-113. doi: 10.1016/j.leukres.2016.05.023. PMID: 27299973
Huang L, Wang SA, DiNardo C, Li S, Hu S, Xu J, Zhou W, Goswami M, Medeiros LJ, Tang G. Tetraploidy/near-tetraploidy acute myeloid leuekmia. Leuk Res. 2016 Dec 2;53:20-27. doi: 10.1016/j.leukres.2016.11.016. PMID: 27951415
Gur HD, Wang SA, Tang Z, Hu S, Li S, Medeiros LJ, Tang G. Clinical significance of isolated del(7p) in myeloid neoplasms. Leuk Res. 2017 Apr;55:18-22. doi: 10.1016/j.leukres.2017.01.016. PMID: 28119224
Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, Goswami M, Yin CC, Lu G, Medeiros LJ, Tang G. Isolated +15 in bone marrow: Disease-associated or a benign finding? Leuk Res. 2015 Jan;39(1):72-6. doi: 10.1016/j.leukres.2014.11.005. PMID: 25435027
Baraban E, Hu S, Hui P, Podoltsev N, Cooper D, Xu ML. Tissue based chimerism analysis enhances detection of donor derived neoplasm in allogeneic stem cell transplant patients. Bone Marrow Transplant. 2017 Apr;52(4):634-637. doi: 10.1038/bmt.2016.332. PMID: 27991892
Wang XI, Yin CC, Qazilbash MH, Hu S, Lu G. Clinical significance of acquired cytogenetic clones in patients with treated follicular lymphoma. Clin Lymphoma Myeloma Leuk. 2015 May;15(5):262-9. doi: 10.1016/j.clml.2014.12.0004. PMID: 25573378
Tang G, Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, DiNardo C, Medeiros LJ. Isolated del(5q) in patients following therapies for various malignancies may not all be clinical significant. Am J Clin Pathol 2015 Jul;144(1);78-86. doi: 10.1309/AJCPBADO22WXOFHJ. PMID: 26071464
Chamoun K, Loghavi S, Pemmaraju N, Konopleva M, Kroll M, Nguyen-Cao M, Hornbaker M, DiNardo CD, Kadia T, Jorgensen J, Andreeff M, Hu S, Benton CB. Early detection of transformation to BPDCN in a patient with MDS. Exp Hematol Oncol 2018 Oct 6;7:26. doi: 10.1186/s40164-018-0117-6. eCollection 2018. PMID: 30323983
Tang G, Hu S, Wang SA, Xie W, Lin P, Xu J, Toruner G, Zhao M, Gu J, Doty M, Li S, Medeiros LJ, Tang Z. t(3;8)(q26.2;q24) often leads to MECOM/MYC rearrangement and is commonly associated with therapy-related myeloid neoplasms and/or disease progression. J Mol Diagn. 2019 Mar;21(2):343-351. doi: 10.1016/j.jmoldx.2018.10.005. PMID: 30576868
Tang Z, Tang G, Hu S, Patel KP, Yin CC, Wang W, Lin P, Toruner GA, OK CY, Gu J, Lu X, Khoury JD, Medeiros LJ. Deciphering the complexities of MECOM rearrangement in myeloid malignancies. Cancer Genet. 2019 Apr;233-234:21-31. doi: 10.1016/j.cancergen.2019.03.002. PMID: 31109591
Xie W, Chen Z, Wang SA, Hu S, Li S, Miranda RN, Medeiros LJ, Tang G. Lymphocytic leukemia following myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms. Leuk Lymphoma. 2019 Dec;60(12):2993-3001. doi: 10.1080/10428194.2019.1605509. PMID: 31017498
Fang H, Wang SA, Xie W, Tang Z, Hu S, Krishnamurthy S, Medeiros LJ, Wang W. Clinicopathologic features of myelodysplastic syndrome involving lymph node. Am J Surg Pathol. 2021 Jul 1;45(7):930-938. doi: 10.1097/PAS.0000000000001689. PMID: 33739784.
Oo, TH, Hu S. Copper deficiency related bone marrow changes secondary to long-term total parenteral nutrition. Clin Case Rep 2017 Feb;5(2):195-196. doi: 10.1002/ccr3.789. PMID: 28174650
Bai B, Lu G, Hu S, Yin CC. t(1;3)(p36;p21) as the sole clonal abnormality in a case of refractory acute myeloid leukemia. N Am J Med Sci. 5:235-238 (2012)
Tang G, Lu X, Wang SA, Roney EK, Zhang L, Hu S, Lu G, Medeiros LJ, Patel A. Homozygous inv(11)(q21q23) and MLL gene rearrangement in two patients with myeloid neoplasms. Int J Clin Exp Pathol. 2014 May 15;7(6):3196-21. eCollection 2014. PMID: 25031740
Sui J, Kelmenson D, Hu S, Cao L. Acute respiratory distress syndrome in a patient with acute promyelocytic leukemia: overlapping between differentiation syndrome and COVID-19. J Hematol. 2021 Oct;10(5):217-220. doi: 10.14740/jh904. PMID: 34804311.
Zhao M, Medeiros LJ, Wang W, Tang G, Jung SK, Sfamenos SM, Fang H, Torunner GA, Hu S, Yin CC, Lin P, Gu J, Peng G, You MJ, Khoury JD, Wang SA, Tang Z. Newly designed breakapart FISH probe helps to identify cases with true MECOM rearrangement in myeloid malignancies. Cancer Genet. 2022 Apr;262-263:23-29. doi: 10.1016/j.cancergen.2021.12.009. PMID: 34974290.
Tang G, Zou Y, Wang SA, Borthakur G, Toruner G, Hu S, Li S, Xu J, Medeiros LJ, Tang Z. 3’ CBFB deletion in CBFB-rearranged acute myeloid leukemia retains morphological features associated with inv(16), but patients have higher risk of relapse and may require stem cell transplant. Ann Hematol. 2022 Apr;101(4):847-854. doi: 10.1007/s00277-022-04767-1. PMID: 35184217.
Fang H, Wang SA, Hu S, Konoplev SN, Mo H, Liu W, Zuo Z, Xu J, Jorgensen J, Yin CC, El Hussein S, Jelloul FZ, Tang Z, Medeiros LJ, Wang W. Acute promyelocytic leukemia: immunophenotype and differential diagnosis by flow cytometry. Cytometry B Clin Cytom. 2022 Jul;102(4):283-291. doi: 10.1002/cyto.b.22085. PMID: 35716019.
Wang W, Xu J, Khoury JD, Pemmaraju N, Fang H, Miranda RN, Yin CC, El Hussein S, Jia F, Tang Z, Hu S, Konoplev M, Medeiros LJ, Wang SA. Immunophenotypic and molecular features of acute myeloid leukemia with plasmacytoid dendritic cell differentiation are distinct from blastic plasmacytoid dendritic cell neoplasm. Cancers (Basel). 2022 Jul 11;14(14):3375. doi: 10.3390/cancers14143375.PMID: 35884435
Xie W, Raess PW, Dunlap J, Hoyos CM, Li H, Li P, Swords R, Olson SB, Yang F, Anekpuritanang T, Hu S, Wiszniewska J, Fan G, Press RD, Moore SR. Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome. Leuk Lymphoma. 2022 Aug;63(8):1907-1916. doi: 10.1080/10428194.2022.2047672. PMID: 35258401.
Fang H, Wang SA, You MJ, Hu S, Miranda RN, Tang Z, Lin P, Jorgensen JL, Xu J, Thakral B, Schlette EJ, EI Hussein S, Bueso-Ramos C, Medeiros LJ, Wang W. Flow cytometry immunophenotypic features of pure erythroid leukemia and its distinction from reactive erythroid precursors. Cytometry B Clin Cytom. 2022 Nov;102(6):440-447. doi: 10.1002/cyto.b.22095. PMID: 36156384.
Fang H, Yabe M, Zhang X, Kim Y, Wu X, Wei P, Chi S, Zheng L, Garcia-Manero G, Shao L, Yuan J, Shen Y, Zheng G, Tang G, Wang W, Loghavi S, Shen Q, Yuan Y, He R, Chen D, Medeiros LJ, Hu S. Myelodysplastic syndrome with t(6;9)(p22;q34.1)/DEK-NUP214 better classified as acute myeloid leukemia? A multicenter study of 107 cases. Mod Pathol. 2021 Jun;34(6):1143-1152. doi: 10.1038/s41379-021-00741-w. PMID: 33558656.
Wang X, Tang G, Hu Z, Fang H, Wang W, Tang Z, Toruner GA, Zhou T, DiNardo CD, Garcia-Manero G, Verstovsek S, Bueso-Ramos CE, Medeiros LJ, Hu S. Myeloid neoplasms with 8q24/MYC rearrangement are frequently associated with myelodysplasia, complex karyotype, TP53 alterations, and inferior survival. Br J Haematol. 2022 Aug;198(3):604-608. doi: 10.1111/bjh.18278. PMID: 35645146.
Zhou T, Curry CV, Khanlari M, Shi M, Cui W, Peker D, Chen W, Wang E, Gao J, Shen Q, Xie W, Jelloul FZ, King RL, Yuan J, Wang X, Zhao C, Obiorah IE, Courville EL, Normura E, Cherian S, Xu ML, Burack WR, Liu HX, Jabbour EJ, Takahashi K, Wang W, Wang SA, Khoury JD, Medeiros LJ, Hu S. Genetics and pathologic landscape of lineage switch of acute leukemia during therapy. Blood Cancer J 2024 Jan 25;14(1):19. doi: 10.1038/s41408-024-00983-2. PMID: 38272888.
Liu H, Hu S. Acute leukemic variant of blastic plasmacytoid dendritic cell neoplasm at initial presentation. Blood. 2020 Apr 23;135(17):1506. doi: 10.1182/blood.2020005039. PMID: 32324873
Liu H, Miao Y, Ferrajoli A, Tang G, McDonnell T, Medeiros LJ, Hu S. Leukemic phase of Richter transformation: a mimic of acute myeloid leukemia that responded to ibrutinib monotherapy. Am J Hematol. 2020 Oct;95(10):1221-1223. doi: 10.1002/ajh.25782. PMID: 32162729
Gong Z, Xu ML, Chen M, Cui W, Kantarjian HM, Cortes JE, Zhou T, Tang G, Wang W, Medeiros LJ, Hu S. Philadelphia chromosome-negative acute leukemia in patients with chronic myeloid leukemia. Am J Hematol. 2019 Oct;94(10):E256-E259. doi: 10.1002/ajh.25571. PMID: 31273842
Xie W, Tang G, Wang E, Young K, Cloe A, Shen Q, Zhou Y, Garcia-Manero G, Loghav S, Hu AY, Wang SA, Bueso-Ramos C, Kantarjian HM, Medeiros LJ, Hu S. t(11;16)(q23;p13)/KMT2A-CREPBP in hematologic neoplasms: presumptive evidence of myelodysplasia or therapy-related neoplasms? Ann Hematol. 2020 Mar;99(3):487-500. doi: 10.1007/s00277-020-03909-7. PMID: 30759270
Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng W, Choi JK, Colmenero I, Coupland SE, Cross NCP, De Jong D, Elghetany MT, Takahashi E, Emile J, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, C Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li X, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A. The 5th Edition of The World Health Organization Classification of Haematolymphoid Tumors: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. PMID: 35732831.
Wang W, Beird H, Kroll CJ, Hu S, Bueso-Ramos CE, Fang H, Tang G, Tang Z, Wang F, Takahashi K, You MJ, Khoury JD, Medeiros LJ, and Futreal PA. t(6;14)(q25;q32) involves BCL11B and is highly associated with mixed phenotype acute leukemia, T/myeloid. Leukemia 2020 Sep;34(9):2509-2512. doi: 10.1038/s41375-020-0761-9. PMID: 32099038
Yang Y, Tang Z, Huang Y, Hu Q, Wang S, Ji J, Du Y, Yang C, Chen M, Hu S, Han B. Sirolimus versus cyclosporine A in patients with primary acquired pure red cell aplasia: a prospective cohort study. Blood Cancer J. 2023 May 10;13(1):74. doi: 10.1038/s41408-023-00845-3. PMID: 37160872
Ronaghy A, Hu S, Tang Z, Wang W, Tang G, Lohgavi S, Li S. Thakral B, Medeiros LJ, Muzzafar T. Myeloid neoplasms associated with t(3;12)(p26.2;p13) are clinical aggressive, show myelodysplasia, and frequently harbor chromosome 7 abnormalities. Mod Pathol. 2021 Feb;34(2):300-313. doi: 10.1038/s41379-020-00663-z. PMID: 33110238.
Zuo Z, Maiti S, Hu S, Loghavi S, Calin GA, Garcia-Manero G, Kantarjian HM, Medeiros LJ, Cooper L, Bueso-Ramos CE. Plasma circulating-microRNA profiles are useful for assessing prognosis in patients with cytogenetically normal myelodysplastic syndromes. Mod Pathol. 2015 Mar;28(3):373-82. doi: 10.1038/modpath.2014.108. PMID: 25216221
Xie W, Xu J, Hu S, Li S, Wang W, Yin CC, Toruner G, Tang Z, Medeiros LJ, Tang G. iAMP21 in acute myeloid leukemia is associated with complex karyotype, TP53 mutation, and dismal outcome. Mod Pathol. 2020 Jul;33(7):1389-1397. doi: 10.1038/s41379-020-0494-3. PMID: 32034282
Goswami RS, Wang SA, Tang Z, Li Y, Zuo W, Hu S, Li S, Medeiros LJ, Tang G. Newly emerged isolated del(7q) in patients with prior cytotoxic therapies may not always be associated with therapy-related myeloid neoplasm. Mod Pathol. 2016 Jul;29(7):727-734. doi: 10.1038/modpath. 2016.67. PMID: 27056073
Xie W, Hu S, Xue J, Chen Z, Medeiros LJ, Tang G. Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults. Ann Hematol. 2019 May;98(5):1149-1157. PMID: 29288910
Hu Z, Hu S, Ji C, Tang Z, Thakral B, Loghavi S, Medeiros LJ, Wang W. 3q26.2/EVI1 rearrangement in myelodysplastic/myeloproliferative neoplasms: an early event associated with a poor prognosis. Leuk Res. 2017 Dec 23;65:25-28. doi: 10.1016/j.leukres.2017.12.004. PMID: 29288910
Bai S, Hu S. BCR-ABL1-negative acute myeloid leukemia relapsing as BCR-ABL1-positive disease. Br J Hematol. 2017 Feb;176(4):514. doi: 10.1111/bjh.14484. PMID: 27982417
Chen F, Hu S, Ruan J, Chen M, Han B. Mutational landscape and its clinical significance in paroxysmal nocturnal hemoglobinuria. Blood Cancer J. 2021 Mar 16;11(3):58. doi: 10.1038/s41408-021-00451-1. PMID: 33727526
Loghavi S, Sui D, Wei P, Garcia-Manero G, Pierce S, Routbort MJ, Jabbour EJ, Pemmaraju N, Kanagal-Shamanna R, Gur HD, Hu S, Zuo Z, Medeiros LJ, Kantarjian HM, Khoury JD. Validation of WHO 2017 Chronic myelomonocytic leukemia categories. Blood Adv. 2018 Aug 14;2(15):1807-1816. doi: 10.1182/bloodadvances.2018019224. PMID: 30054307
Tang G, Zhang L, Fu B, Hu J, Lu X, Hu S, Patel A, Goswami M, Khoury JD, Garcia-Manero G, Medeiros LJ, Wang SA. Cytogenetic risk stratification of 417 patients with chronic myelomonocytic leukemia from a single institute. Am J Hematol. 2014 Aug;89(8):813-8. doi: 10.1002/ajh.23751. PMID: 24782398
Tang G, Fu B, Hu S, Lu X, Tang Z, Li S, Jabbar K, Khoury JD, Medeiros LJ, Wang SA. Prognostic impact of acquisition of cytogenetic abnormalities during the course of chronic myelomonocytic leukemia. Am J Hematol. 2015 Oct;90(10):882-7. doi: 10.1002/ajh.24108. PMID: 26148174
Wang SA, Jorgensen JL, Hu S, Jia F, Li S, Loghavi S, Ok CY, Thakral B, Xu J, Medeiros LJ, Wang W. Validation of a 12-color multicolor flow cytometry assay for acute myeloid leukemia minimal residual/measurable disease detection. Cytometry B Clin Cytom. 2023 Sep;104(5):356-366. doi: 10.1002/cyto.b.22140. PMID: 37605812
Salem A, Loghavi S, Tang G, Huh YO, Jabbour EJ, Kantarjian H, Wang W, Hu S, Luthra R, Medeiros LJ, Khoury J. Myeloid neoplasms with concurrent BCR-ABL1 and CBFB rearrangements: a series of 10 cases of a clinically aggressive neoplasm. Am J Hematol. 2017 Jun;92(6):520-528. doi: 10.1002/ajh.24710. 28253536
Abou Dalle I, Kantarjian H, Bannon SA, Kanagal Shamanna R, Routbort M, Patel KP, Hu S, Bhalla K, Garcia-Manero G, DiNardo CD. Successful lenalidomide treatment in high risk myelodysplastic syndrome with germline DDX41 mutation. Am J Hematol. 2020 Feb;95(2):227-229. doi: 10.1002/ajh.25610. PMID: 31400013
El Hussein S, Hu S, Fang H, Garces S, Muzzafar T, Wang SA, Medeiros LJ, Bueso-Ramos CE, Jelloul FZ. Well-differentiated systemic mastocytosis with associated myeloid sarcoma and myelodysplastic syndrome: diagnostic challenges of an under-recognized entity. Leuk Lymphoma. 2022 Jan;63(1):235-238. doi: 10.1080/10428194.2021.1978089. PMID: 34510998.
Boddu PC, Wang S, Pemmaraju N, Tang Z, Hu S, Li S, Xu J, Medeiros LJ, Tang G. 8q24/MYC rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms. Leuk Res. 2018 Mar;66:73-78. doi: 10.1016/j.leukres.2018.01.013. PMID: 29407586
Tang Z, Li Y, Wang W, Yin CC, Tang G, Aung PP, Hu S, Lu X, Toruner GA, Medeiros LJ, Khoury JD. Genomic alterations involving 12p/ETV6 are highly prevalent in blastic plasmacytoid dendritic cell neoplasms and might represent early clonal events. Leuk Res 2018 Oct; 73: 86-94. doi: 10.1016/j.leukres.2018.09.006. PMID: 30248580
Tang Z, Li Y, Wang SA, Hu S, Li S, Lu X, Khoury JD, Medeiros LJ, Tang G. Clinical significance of acquired loss of X chromosome in bone marrow. Leuk Res. 2016 May 27;47:109-113. doi: 10.1016/j.leukres.2016.05.023. PMID: 27299973
Huang L, Wang SA, DiNardo C, Li S, Hu S, Xu J, Zhou W, Goswami M, Medeiros LJ, Tang G. Tetraploidy/near-tetraploidy acute myeloid leuekmia. Leuk Res. 2016 Dec 2;53:20-27. doi: 10.1016/j.leukres.2016.11.016. PMID: 27951415
Gur HD, Wang SA, Tang Z, Hu S, Li S, Medeiros LJ, Tang G. Clinical significance of isolated del(7p) in myeloid neoplasms. Leuk Res. 2017 Apr;55:18-22. doi: 10.1016/j.leukres.2017.01.016. PMID: 28119224
Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, Goswami M, Yin CC, Lu G, Medeiros LJ, Tang G. Isolated +15 in bone marrow: Disease-associated or a benign finding? Leuk Res. 2015 Jan;39(1):72-6. doi: 10.1016/j.leukres.2014.11.005. PMID: 25435027
Baraban E, Hu S, Hui P, Podoltsev N, Cooper D, Xu ML. Tissue based chimerism analysis enhances detection of donor derived neoplasm in allogeneic stem cell transplant patients. Bone Marrow Transplant. 2017 Apr;52(4):634-637. doi: 10.1038/bmt.2016.332. PMID: 27991892
Wang XI, Yin CC, Qazilbash MH, Hu S, Lu G. Clinical significance of acquired cytogenetic clones in patients with treated follicular lymphoma. Clin Lymphoma Myeloma Leuk. 2015 May;15(5):262-9. doi: 10.1016/j.clml.2014.12.0004. PMID: 25573378
Tang G, Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, DiNardo C, Medeiros LJ. Isolated del(5q) in patients following therapies for various malignancies may not all be clinical significant. Am J Clin Pathol 2015 Jul;144(1);78-86. doi: 10.1309/AJCPBADO22WXOFHJ. PMID: 26071464
Chamoun K, Loghavi S, Pemmaraju N, Konopleva M, Kroll M, Nguyen-Cao M, Hornbaker M, DiNardo CD, Kadia T, Jorgensen J, Andreeff M, Hu S, Benton CB. Early detection of transformation to BPDCN in a patient with MDS. Exp Hematol Oncol 2018 Oct 6;7:26. doi: 10.1186/s40164-018-0117-6. eCollection 2018. PMID: 30323983
Tang G, Hu S, Wang SA, Xie W, Lin P, Xu J, Toruner G, Zhao M, Gu J, Doty M, Li S, Medeiros LJ, Tang Z. t(3;8)(q26.2;q24) often leads to MECOM/MYC rearrangement and is commonly associated with therapy-related myeloid neoplasms and/or disease progression. J Mol Diagn. 2019 Mar;21(2):343-351. doi: 10.1016/j.jmoldx.2018.10.005. PMID: 30576868
Tang Z, Tang G, Hu S, Patel KP, Yin CC, Wang W, Lin P, Toruner GA, OK CY, Gu J, Lu X, Khoury JD, Medeiros LJ. Deciphering the complexities of MECOM rearrangement in myeloid malignancies. Cancer Genet. 2019 Apr;233-234:21-31. doi: 10.1016/j.cancergen.2019.03.002. PMID: 31109591
Xie W, Chen Z, Wang SA, Hu S, Li S, Miranda RN, Medeiros LJ, Tang G. Lymphocytic leukemia following myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms. Leuk Lymphoma. 2019 Dec;60(12):2993-3001. doi: 10.1080/10428194.2019.1605509. PMID: 31017498
Fang H, Wang SA, Xie W, Tang Z, Hu S, Krishnamurthy S, Medeiros LJ, Wang W. Clinicopathologic features of myelodysplastic syndrome involving lymph node. Am J Surg Pathol. 2021 Jul 1;45(7):930-938. doi: 10.1097/PAS.0000000000001689. PMID: 33739784.
Oo, TH, Hu S. Copper deficiency related bone marrow changes secondary to long-term total parenteral nutrition. Clin Case Rep 2017 Feb;5(2):195-196. doi: 10.1002/ccr3.789. PMID: 28174650
Bai B, Lu G, Hu S, Yin CC. t(1;3)(p36;p21) as the sole clonal abnormality in a case of refractory acute myeloid leukemia. N Am J Med Sci. 5:235-238 (2012)
Tang G, Lu X, Wang SA, Roney EK, Zhang L, Hu S, Lu G, Medeiros LJ, Patel A. Homozygous inv(11)(q21q23) and MLL gene rearrangement in two patients with myeloid neoplasms. Int J Clin Exp Pathol. 2014 May 15;7(6):3196-21. eCollection 2014. PMID: 25031740
Sui J, Kelmenson D, Hu S, Cao L. Acute respiratory distress syndrome in a patient with acute promyelocytic leukemia: overlapping between differentiation syndrome and COVID-19. J Hematol. 2021 Oct;10(5):217-220. doi: 10.14740/jh904. PMID: 34804311.
Zhao M, Medeiros LJ, Wang W, Tang G, Jung SK, Sfamenos SM, Fang H, Torunner GA, Hu S, Yin CC, Lin P, Gu J, Peng G, You MJ, Khoury JD, Wang SA, Tang Z. Newly designed breakapart FISH probe helps to identify cases with true MECOM rearrangement in myeloid malignancies. Cancer Genet. 2022 Apr;262-263:23-29. doi: 10.1016/j.cancergen.2021.12.009. PMID: 34974290.
Tang G, Zou Y, Wang SA, Borthakur G, Toruner G, Hu S, Li S, Xu J, Medeiros LJ, Tang Z. 3’ CBFB deletion in CBFB-rearranged acute myeloid leukemia retains morphological features associated with inv(16), but patients have higher risk of relapse and may require stem cell transplant. Ann Hematol. 2022 Apr;101(4):847-854. doi: 10.1007/s00277-022-04767-1. PMID: 35184217.
Fang H, Wang SA, Hu S, Konoplev SN, Mo H, Liu W, Zuo Z, Xu J, Jorgensen J, Yin CC, El Hussein S, Jelloul FZ, Tang Z, Medeiros LJ, Wang W. Acute promyelocytic leukemia: immunophenotype and differential diagnosis by flow cytometry. Cytometry B Clin Cytom. 2022 Jul;102(4):283-291. doi: 10.1002/cyto.b.22085. PMID: 35716019.
Wang W, Xu J, Khoury JD, Pemmaraju N, Fang H, Miranda RN, Yin CC, El Hussein S, Jia F, Tang Z, Hu S, Konoplev M, Medeiros LJ, Wang SA. Immunophenotypic and molecular features of acute myeloid leukemia with plasmacytoid dendritic cell differentiation are distinct from blastic plasmacytoid dendritic cell neoplasm. Cancers (Basel). 2022 Jul 11;14(14):3375. doi: 10.3390/cancers14143375.PMID: 35884435
Xie W, Raess PW, Dunlap J, Hoyos CM, Li H, Li P, Swords R, Olson SB, Yang F, Anekpuritanang T, Hu S, Wiszniewska J, Fan G, Press RD, Moore SR. Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome. Leuk Lymphoma. 2022 Aug;63(8):1907-1916. doi: 10.1080/10428194.2022.2047672. PMID: 35258401.
Fang H, Wang SA, You MJ, Hu S, Miranda RN, Tang Z, Lin P, Jorgensen JL, Xu J, Thakral B, Schlette EJ, EI Hussein S, Bueso-Ramos C, Medeiros LJ, Wang W. Flow cytometry immunophenotypic features of pure erythroid leukemia and its distinction from reactive erythroid precursors. Cytometry B Clin Cytom. 2022 Nov;102(6):440-447. doi: 10.1002/cyto.b.22095. PMID: 36156384.