ALL, TCL, and PCN
Shen Q, Jabbour EJ, Tang G, Fang H, Wang W, Short NJ, You MJ, Medeiros LJ, Hu S. Secondary acquisition of the Philadelphia chromosome in acute lymphoblastic leukemia. Am J Hematol 2024 Aug 17. doi: 10.1002/ajh.27462. PMID: 39152741. Online ahead of print.
Hu S, Jabbour EJ, Hu CY, Tang G, Wang W, Medeiros LJ, Bueso-Ramos C. Recurrent lymphoid and myeloid relapses due to treatment cessations reveal natural history of Ph-positive B-ALL and poses a diagnostic challenge. Am J Hematol. 2024 Apr;99(4):721-726. doi: 10.1002/ajh.27210. PMID: 38240333.
Hu S, Young KH, Konoplev SN, Medeiros LJ. Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphoma. Hum Pathol. 2012 Nov;43(11):1789-98. doi: 10.1016/j.humpath.2012.05.002. PMID: 22959759
Zheng L, Hu S. Philadelphia chromosome-positive B-lymphoblastic lymphoma involves genitourinary system and bone at initial diagnosis and at relapse. Blood. 2017 Sep 21;130(12):1483. doi: 10.1182/blood-2017-05-785626. PMID: 28935645
Chen Z & Hu S. MYC/BCL2 double-hit lymphoma mimicking acute leukemia at initial presentation. Blood. 2016 Feb 25;127(8):1072. doi: 10.1182/blood-2015-11-683730. PMID: 27351033
Wang W & Hu S. Neoplastic plasma cells mimicking mature neutrophils in plasma cell myeloma with t(11;14)(q13;q32). Blood. 2015 Apr 30;125(18):2875. doi: 10.1182/blood-2014-12-617795. PMID: 26120642
Wang W & Hu S. Cup-like blasts in B-lymphoblastic leukemia. Br J Hematol. 2015 Sep;170(5):596. doi: 10.111/bjh.13541. PMID: 26120642. PMID: 26132718
Quesada AE, Hu S, Li S, Toruner GA, Wei Q, Loghavi S, Ok CY, Jain P, Thakral B, Nwogbo V, Kim D, Iyer SP, You MJ, Medeiros LJ, Tang G. Optical genomic mapping is a helpful tool for detecting CCND1 rearrangements in CD5-negative small B-cell lymphoma: two cases of leukemic non-nodal mantle cell lymphoma. Hum Pathol. 2024 Feb;144:71-76. doi: 10.1016/j.humpath.2024.01.012. PMID: 38301962.
Yuan J, Liu H, Hu S, Roberto MN, Xu X, Bayerl MG, Artymiuk CJ, Berg H, King R, Shi M, He R, Viswanatha D, McPhail ED. Follicular lymphoma and diffuse large B-cell lymphoma with BCL2 and IRF4 rearrangements in adult patients. Hum Pathol. 2023 Nov;141:22-29. doi: 10.1016/j.humpath.2023.08.008. PMID: 37634651
Fang H, Beird HC, Wang SA, Ibrahim A, Tang Z, Tang G, You MJ, Hu S, Xu J, Li S, Yin CC, El Hussein S, Le N, Futreal PA, Bueso-Ramos C, Thakral B, Kadia T, Thornton R, Little L, Gumbs C, Song X, Medeiros LJ, Wang W. T-prolymphocytic leukemia: TCL1 or MTCP1 rearrangement is not mandatory to establish diagnosis. Leukemia 2023 Sep;37(9):1919-1921. doi: 10.1038/s41375-023-01956-3. PMID: 37443196
Tang G, Wu Y, Lin P, Toruner GA, Hu S, Li S, Qazilbash MH, Orlowski R, Ye C, Xu J, Nahmod KA, Medeiros LJ, Tang Z. Cytogenetic profile in monoclonal gammopathy of undetermined significance, smoldering and symptomatic multiple myeloma: a study of 1087 patients with highly purified plasma cells. Cancers (Basel). 2023 Dec 2;15(23):5690. doi: 10.3390/cancers15235690. PMID: 38067393
Geethakumari PR, Hoffmann MS, Pemmaraju N, Hu S, Jorgensen JL, O’Brien S, Daver N. Extremedullary B lymphoblastic leukemia/lymphoma (B-ALL/LBL): a diagnostic challenge. Clin Lymphoma Myeloma Leuk. 2014 Aug;14(4):e115-8. doi: 10.1016/j.clml.2014.01.004. PMID: 24589157
Liu W, Hu S, Konopleva M, Khoury JD, Kalhor N, Tang G, Bueso-Ramos CE, Jorgensen JL, Lin P, Medeiros LJ, Lu X. De novo MYC and BCL2 double-hit B-Cellprecursor acute lymphoblastic leukemia (BCP-ALL) in pediatric and young adult patients associated with poor prognosis. Pediatr Hematol Oncol. 2015 Nov;32(8):535-47. doi: 10.3109/08880018.2015.1087611. PMID: 26558423
Yabe M, Medeiros LJ, Tang G, Wang SA, Ahmed S, Nieto Y, Hu S, Bhagat G, Oki Y, Patel KP, Routbort M, Luthra R, Fanale MA, Bueso-Ramos CE, Jorgensen JL, Vega F, Chen W, Hoehn D, Konoplev S, Milton DR, Bassett R, Wistuba I, Li S, You MJ, Young KH, Miranda RN. Prognostic factors of hepatosplenic T-cell lymphoma: clinicopathologic study of 28 cases. Am J Surg Pathol. 2016 May;40(5):676-88. Doi: 10.1097/PAS.0000000000000614. PMID: 26872013
Agbay RL, Torres-Cabala CA, Patel KP, Merril ED, Duvic M, Quesada A, Prieto VG, Aung PP, Loghavi S, Young KH, Hu S, Ferrufino-Schmidt MC, Tetzlaff M, Li S, Medeiros LJ, Miranda RN. Immunophenotypic shifts in primary cutaneous γδ T-cell lymphoma suggest antigenic modulation: a study of sequential biopsy specimens. Am J Surg Pathol. 2017 Apr;41(4):431-445. doi: 10.1097/PAS.0000000000000786. PMID: 28248813
Hu Z, Medeiros LJ, Fang L, Sun Y, Tang Z, Tang G, Sun T, Quesada AE, Hu S, Wang SA, Lin P, Lu X. Prognostic significance of cytogenetic abnormalities in T-cell prolymphocytic leukemia. Am J Hematol. 2017 May;92(5):441-447. doi: 10.1002/ajh.24679. PMID: 28194886
Chen Z, Sun Y, Xie W, Wang S, Hu S, Li S, Tang Z, Toruner G, Medeiros LJ, Tang G. Is hyperdiploidy a favorable cytogenetics in adults with B-lymphoblastic Leukemia? Cancer Med. 2019 Aug;8(9):4093-4099. doi: 10.1002/cam4.2255. PMID: 31173486
Shen J, Medeiros LJ, Li S, Wang SA, Lin P, Khanlari M, Iyer SP, Yin CC, Tang G, Jorgensen JL, Hu S, Miranda RN, Xu J. CD8 expression in anaplastic large cell lymphoma correlates with non-common morphologic variants and T-cell antigen expression suggesting biological differences with CD8-negative anaplastic large cell lymphoma. Human Pathol. 2020 Apr;98:1-9. doi: 10.1016/j.humpath.2020.01.005. PMID: 32032618
Wang Z, Gong Q, Zhao Y, Xu H, Hu S, Zhang Z. EBV-positive T-cell lymphoproliferative disorder arising in a chronic pericardial hematoma: T-cell counterpart of fibrin-associated diffuse large B-cell lymphoma? Haematologica. 2020 Aug;105(8):e437-e439. doi: 10.3324/haematol.2020.252007. PMID: 32414846
Wang W, Beird H, Kroll CJ, Hu S, Bueso-Ramos CE, Fang H, Tang G, Tang Z, Wang F, Takahashi K, You MJ, Khoury JD, Medeiros LJ, and Futreal PA. t(6;14)(q25;q32) involves BCL11B and is highly associated with mixed phenotype acute leukemia, T/myeloid. Leukemia 2020 Sep;34(9):2509-2512. doi: 10.1038/s41375-020-0761-9. PMID: 32099038
Hao S, Lu X, Gong Z, Bassett RL, Hu S, Konoplev SN, Tang G, Li S, Xu J, Khanlari M, Lee HC, Manasanch EE, Weber DM, Orlowski RZ, Medeiros LJ, Lin P. The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma. Mod Pathol. 2021 Feb;34(2):327-335. doi: 10.1038/s41379-020-00669-7. PMID: 32908255.
Xiang C, Wu W, Fan M, Wang Z, Feng X, Liu C, Liu J, Liu G, Xia L, Si H, Gu Y, Liu N, Luo D, Wang Y, Ma D, Hu S, Liu H. Phosphorylated STAT3 as a potential diagnostic and predictive marker in ALK- ALCL vs. CD30high PTCL, NOS. Front Immunol 2023 Jun 14;14:1132834. doi: 10.3389/fimmu.2023.1132834. eCollection 2023. PMID: 37388733
Ghosh A, Chen L, Wahed A, Wang W, Saluja K, Nguyen AND, Hu S, Hu Z. Incidental but rapidly progressing T-cell prolymphocytic leukemia with t(X;14)(q28;q11) involving parotid lymphoepithelial cysts: a diagnostic pitfall. Int J Lab Hematol. 2022 Feb;44(1):e17-e20. doi: 10.1111/ijlh.13662. PMID: 34275205.
El Hussein S, Medeiros LJ, Hu S, Lin P, Wang W. The many faces of plasma cell neoplasms: morphological and immunophenotypical variants of the great imitator. Pathology. 2022 Feb;54(1):32-42. doi: 10.1016/j.pathol.2021.09.011. PMID: 34887091.
Fang H, Khoury JD, Torres-Cabala CA, Ng SB, Xu J, El Hussein S, Hu S, Vega F, Li S, Tang Z, Tang G, Medeiros LJ, Wang W. Expression pattern and diagnostic utility of BCL11B in mature T- and NK-cell neoplasms. Pathology. 2022 Dec;54(7):893-899. doi: 10.1016/j.pathol.2022.04.012. PMID: 35864006.
Hu Z, Medeiros LJ, Xu M, Yuan J, Peker D, Shao L, Tang Z, Mai B, Thakral B, Rio A, Hu S, Wang W. T-cell prolymphocytic leukemia with t(X;14)(q28;q11.2): a clinicopathologic study of 15 cases. Am J Clin Pathol 2023 Apr 4;159(4):325-336. doi: 10.1093/ajcp/aqac166. PMID: 36883805.
Hu S, Jabbour EJ, Hu CY, Tang G, Wang W, Medeiros LJ, Bueso-Ramos C. Recurrent lymphoid and myeloid relapses due to treatment cessations reveal natural history of Ph-positive B-ALL and poses a diagnostic challenge. Am J Hematol. 2024 Apr;99(4):721-726. doi: 10.1002/ajh.27210. PMID: 38240333.
Hu S, Young KH, Konoplev SN, Medeiros LJ. Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphoma. Hum Pathol. 2012 Nov;43(11):1789-98. doi: 10.1016/j.humpath.2012.05.002. PMID: 22959759
Zheng L, Hu S. Philadelphia chromosome-positive B-lymphoblastic lymphoma involves genitourinary system and bone at initial diagnosis and at relapse. Blood. 2017 Sep 21;130(12):1483. doi: 10.1182/blood-2017-05-785626. PMID: 28935645
Chen Z & Hu S. MYC/BCL2 double-hit lymphoma mimicking acute leukemia at initial presentation. Blood. 2016 Feb 25;127(8):1072. doi: 10.1182/blood-2015-11-683730. PMID: 27351033
Wang W & Hu S. Neoplastic plasma cells mimicking mature neutrophils in plasma cell myeloma with t(11;14)(q13;q32). Blood. 2015 Apr 30;125(18):2875. doi: 10.1182/blood-2014-12-617795. PMID: 26120642
Wang W & Hu S. Cup-like blasts in B-lymphoblastic leukemia. Br J Hematol. 2015 Sep;170(5):596. doi: 10.111/bjh.13541. PMID: 26120642. PMID: 26132718
Quesada AE, Hu S, Li S, Toruner GA, Wei Q, Loghavi S, Ok CY, Jain P, Thakral B, Nwogbo V, Kim D, Iyer SP, You MJ, Medeiros LJ, Tang G. Optical genomic mapping is a helpful tool for detecting CCND1 rearrangements in CD5-negative small B-cell lymphoma: two cases of leukemic non-nodal mantle cell lymphoma. Hum Pathol. 2024 Feb;144:71-76. doi: 10.1016/j.humpath.2024.01.012. PMID: 38301962.
Yuan J, Liu H, Hu S, Roberto MN, Xu X, Bayerl MG, Artymiuk CJ, Berg H, King R, Shi M, He R, Viswanatha D, McPhail ED. Follicular lymphoma and diffuse large B-cell lymphoma with BCL2 and IRF4 rearrangements in adult patients. Hum Pathol. 2023 Nov;141:22-29. doi: 10.1016/j.humpath.2023.08.008. PMID: 37634651
Fang H, Beird HC, Wang SA, Ibrahim A, Tang Z, Tang G, You MJ, Hu S, Xu J, Li S, Yin CC, El Hussein S, Le N, Futreal PA, Bueso-Ramos C, Thakral B, Kadia T, Thornton R, Little L, Gumbs C, Song X, Medeiros LJ, Wang W. T-prolymphocytic leukemia: TCL1 or MTCP1 rearrangement is not mandatory to establish diagnosis. Leukemia 2023 Sep;37(9):1919-1921. doi: 10.1038/s41375-023-01956-3. PMID: 37443196
Tang G, Wu Y, Lin P, Toruner GA, Hu S, Li S, Qazilbash MH, Orlowski R, Ye C, Xu J, Nahmod KA, Medeiros LJ, Tang Z. Cytogenetic profile in monoclonal gammopathy of undetermined significance, smoldering and symptomatic multiple myeloma: a study of 1087 patients with highly purified plasma cells. Cancers (Basel). 2023 Dec 2;15(23):5690. doi: 10.3390/cancers15235690. PMID: 38067393
Geethakumari PR, Hoffmann MS, Pemmaraju N, Hu S, Jorgensen JL, O’Brien S, Daver N. Extremedullary B lymphoblastic leukemia/lymphoma (B-ALL/LBL): a diagnostic challenge. Clin Lymphoma Myeloma Leuk. 2014 Aug;14(4):e115-8. doi: 10.1016/j.clml.2014.01.004. PMID: 24589157
Liu W, Hu S, Konopleva M, Khoury JD, Kalhor N, Tang G, Bueso-Ramos CE, Jorgensen JL, Lin P, Medeiros LJ, Lu X. De novo MYC and BCL2 double-hit B-Cellprecursor acute lymphoblastic leukemia (BCP-ALL) in pediatric and young adult patients associated with poor prognosis. Pediatr Hematol Oncol. 2015 Nov;32(8):535-47. doi: 10.3109/08880018.2015.1087611. PMID: 26558423
Yabe M, Medeiros LJ, Tang G, Wang SA, Ahmed S, Nieto Y, Hu S, Bhagat G, Oki Y, Patel KP, Routbort M, Luthra R, Fanale MA, Bueso-Ramos CE, Jorgensen JL, Vega F, Chen W, Hoehn D, Konoplev S, Milton DR, Bassett R, Wistuba I, Li S, You MJ, Young KH, Miranda RN. Prognostic factors of hepatosplenic T-cell lymphoma: clinicopathologic study of 28 cases. Am J Surg Pathol. 2016 May;40(5):676-88. Doi: 10.1097/PAS.0000000000000614. PMID: 26872013
Agbay RL, Torres-Cabala CA, Patel KP, Merril ED, Duvic M, Quesada A, Prieto VG, Aung PP, Loghavi S, Young KH, Hu S, Ferrufino-Schmidt MC, Tetzlaff M, Li S, Medeiros LJ, Miranda RN. Immunophenotypic shifts in primary cutaneous γδ T-cell lymphoma suggest antigenic modulation: a study of sequential biopsy specimens. Am J Surg Pathol. 2017 Apr;41(4):431-445. doi: 10.1097/PAS.0000000000000786. PMID: 28248813
Hu Z, Medeiros LJ, Fang L, Sun Y, Tang Z, Tang G, Sun T, Quesada AE, Hu S, Wang SA, Lin P, Lu X. Prognostic significance of cytogenetic abnormalities in T-cell prolymphocytic leukemia. Am J Hematol. 2017 May;92(5):441-447. doi: 10.1002/ajh.24679. PMID: 28194886
Chen Z, Sun Y, Xie W, Wang S, Hu S, Li S, Tang Z, Toruner G, Medeiros LJ, Tang G. Is hyperdiploidy a favorable cytogenetics in adults with B-lymphoblastic Leukemia? Cancer Med. 2019 Aug;8(9):4093-4099. doi: 10.1002/cam4.2255. PMID: 31173486
Shen J, Medeiros LJ, Li S, Wang SA, Lin P, Khanlari M, Iyer SP, Yin CC, Tang G, Jorgensen JL, Hu S, Miranda RN, Xu J. CD8 expression in anaplastic large cell lymphoma correlates with non-common morphologic variants and T-cell antigen expression suggesting biological differences with CD8-negative anaplastic large cell lymphoma. Human Pathol. 2020 Apr;98:1-9. doi: 10.1016/j.humpath.2020.01.005. PMID: 32032618
Wang Z, Gong Q, Zhao Y, Xu H, Hu S, Zhang Z. EBV-positive T-cell lymphoproliferative disorder arising in a chronic pericardial hematoma: T-cell counterpart of fibrin-associated diffuse large B-cell lymphoma? Haematologica. 2020 Aug;105(8):e437-e439. doi: 10.3324/haematol.2020.252007. PMID: 32414846
Wang W, Beird H, Kroll CJ, Hu S, Bueso-Ramos CE, Fang H, Tang G, Tang Z, Wang F, Takahashi K, You MJ, Khoury JD, Medeiros LJ, and Futreal PA. t(6;14)(q25;q32) involves BCL11B and is highly associated with mixed phenotype acute leukemia, T/myeloid. Leukemia 2020 Sep;34(9):2509-2512. doi: 10.1038/s41375-020-0761-9. PMID: 32099038
Hao S, Lu X, Gong Z, Bassett RL, Hu S, Konoplev SN, Tang G, Li S, Xu J, Khanlari M, Lee HC, Manasanch EE, Weber DM, Orlowski RZ, Medeiros LJ, Lin P. The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma. Mod Pathol. 2021 Feb;34(2):327-335. doi: 10.1038/s41379-020-00669-7. PMID: 32908255.
Xiang C, Wu W, Fan M, Wang Z, Feng X, Liu C, Liu J, Liu G, Xia L, Si H, Gu Y, Liu N, Luo D, Wang Y, Ma D, Hu S, Liu H. Phosphorylated STAT3 as a potential diagnostic and predictive marker in ALK- ALCL vs. CD30high PTCL, NOS. Front Immunol 2023 Jun 14;14:1132834. doi: 10.3389/fimmu.2023.1132834. eCollection 2023. PMID: 37388733
Ghosh A, Chen L, Wahed A, Wang W, Saluja K, Nguyen AND, Hu S, Hu Z. Incidental but rapidly progressing T-cell prolymphocytic leukemia with t(X;14)(q28;q11) involving parotid lymphoepithelial cysts: a diagnostic pitfall. Int J Lab Hematol. 2022 Feb;44(1):e17-e20. doi: 10.1111/ijlh.13662. PMID: 34275205.
El Hussein S, Medeiros LJ, Hu S, Lin P, Wang W. The many faces of plasma cell neoplasms: morphological and immunophenotypical variants of the great imitator. Pathology. 2022 Feb;54(1):32-42. doi: 10.1016/j.pathol.2021.09.011. PMID: 34887091.
Fang H, Khoury JD, Torres-Cabala CA, Ng SB, Xu J, El Hussein S, Hu S, Vega F, Li S, Tang Z, Tang G, Medeiros LJ, Wang W. Expression pattern and diagnostic utility of BCL11B in mature T- and NK-cell neoplasms. Pathology. 2022 Dec;54(7):893-899. doi: 10.1016/j.pathol.2022.04.012. PMID: 35864006.
Hu Z, Medeiros LJ, Xu M, Yuan J, Peker D, Shao L, Tang Z, Mai B, Thakral B, Rio A, Hu S, Wang W. T-cell prolymphocytic leukemia with t(X;14)(q28;q11.2): a clinicopathologic study of 15 cases. Am J Clin Pathol 2023 Apr 4;159(4):325-336. doi: 10.1093/ajcp/aqac166. PMID: 36883805.